A Better Way to Distinguish Among Melanomas? Contemporary Approaches to Malignant Melanoma From melanocytes to melanomas Nature Reviews Cancer Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in COM Jan. 2008 Diagnosis UW School of Dentistry Pigmented (Purple or Brown) Lesions in the Mouth Pigmented (Purple or Brown) Lesions in the Mouth Kazemi Oral Surgery Facialart.com COM March 2009 Diagnosis UW School of Dentistry